![]() A much larger experience recorded hepatitis in 4.6% of patients older than 65. The number in the elderly was probably falsely low because of a small sample size. 240 The incidence in daily drinkers of alcohol was also high (26.). ![]() 361 A US Public Health Service survey found that the incidence of probable INH-associated hepatitis increased with age: Rates per 1000 persons were 0 for those younger than age 20, 3 for ages 20 to 34, 12 for ages 35 to 49, 23 for ages 50 to 64, and 8 for age older than 64. Use of INH is associated with an increased risk for hepatotoxicity the risk in a recent clinical trial of 9 months of INH was 2.7%. Bennett MD, in Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 2020 Risk for Isoniazid Hepatotoxicity During Treatment of Latent Tuberculous Infection
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